smooth endoplasmic reticulum molecular chaperone

Moreover, organelle destruction impedes their crosstalk and disorder of the internal environment drives disease progression. Abnormal organelle functions or structures are observed in various diseases, including cancer, Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis with associated frontotemporal dementia. Increasing evidence suggests that defects in organelle communication may play a role in the pathogenesis of many human diseases. However, little is known about the mechanisms and functions of organelle interactions. Organelle crosstalk network stability is highly significant in the internal environment. Cellular homeostasis is maintained by organelle cooperation and contact, which enables rapid material and information exchange and execution of various biological processes under different conditions. The spatial regionalization and functional differentiation of organelles are being recognized with ongoing research in the fields of biochemistry and molecular biology. Organelles, which are membrane structures with specific morphologies and functions, are the specialized areas in which eukaryotic cells perform activities necessary for life. It also highlights the application potential of organelle homeostasis maintenance as a preventative and treatment strategy for diseases.

This paper systematically summarized the latest research advances in the synergistic mechanism between the endoplasmic reticulum and mitochondria and their crosstalk with other organelles based on recent literature. Furthermore, the intricate association between organelle dyshomeostasis and the progression of many human diseases remains unclear. However, the mode and mechanism of organelle crosstalk is still a research challenge. Homeostasis and orchestrated interactions are essential for maintaining the normal activities of cells.

The endoplasmic reticulum (ER) and mitochondria are crucial organelles in eukaryotic cells as they are the material synthesis and oxidative metabolism centers, respectively. Disorder of organelle networks often occur in various diseases. Each organelle performs specific functions however, highly coordinated crosstalk occurs between them. Organelles are functional areas where eukaryotic cells perform processes necessary for life.

Smooth endoplasmic reticulum molecular chaperone